Some Thoughts On Ubiquinol & Pyrroloquinoline Quinone (PQQ)


Pyrroloquinoline quinone, or PQQ, is what is called a quinoprotein, which is medicalese to mean that it is an enzyme that helps with a specific reaction. Wait, back up, what’s an enzyme? Well, an enzyme is a compound that helps a chemical reaction occur. Chemicals, wait what! That sounds dangerous. Hold up, wait a sec, we have 37 thousand billion billion chemical reactions happening in our body every SECOND, assuming that Quora answer is correct. Yeah okay let’s put that in perspective. That is 37 times the number of stars there are estimated to be in the observable universe! WOW, okay, so chemical reactions are important for life. Back to PQQ, now.
PQQ’s mechanism as an enzyme has been shown to have an antioxidant effect, and I am going out on a limb here, but it seems to be associated with the control that it has over the process of molecules gaining and losing electrons, which results in oxidation. It’s probably much more complicated than that, but there you go. What I find more interesting, actually, is the effect that it has on cellular metabolism and respiration, which is probably an effect of this “redox modulation” – the effect that it has in the process of cells gaining and losing electrons, or modulating oxidation, or it’s action as an antioxidant.
Now, when I hear the word “cellular respiration”, it makes me breathe freer. Having struggled with asthma in the past, and being addicted to smoking, my worst nightmare is not being able to breathe freely. Now, I know that the effect of PQQ isn’t on the lungs, it’s at the cellular level, but when I started to study PQQ, ubiquinol, and the like, and I saw this effect of increased cellular respiration, I was excited to try it. Could it make me run further or faster? How about strength training. These are all things that I thought to myself, in a purely speculative fashion, as is usually my pattern of thought.



Cellular Respiration

First of all let’s get some definitions out of the way. What is Cellular Respiration? I am going to explain this in reference to cancer, because… Why not. Muscles need energy, and that energy comes in the form of Adenosine Triphosophate. Cells have different ways to make this thing called ATP, and one of them is called fermentation, but healthy cells only use fermentation to create ATP if there is no oxygen available to the cell. Otherwise, they uses that oxygen in cellular respiration to create ATP so that we have energy.
Cancerous cells, on the other hand, ignore that oxygen as if it isn’t there, and use fermentation to create ATP, anyway. This is called the “Warburg effect”, and it is the basis for an interesting theory in cancer research that cancer is a metabolic disorder. But wait a second, is cancer the reason that this happens, or is it just an effect that cancer has, a symptom of cancer, rather than the cause. Good point, and that’s where cancer research is today. Is it the truth, though?


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